Huene is a surname and given name. Notable people with the name include:

• Oswald von Hoyningen-Huene (1885-1963), German diplomat
• Friedrich von Huene (1875–1969), German paleontologist
• George Hoyningen-Huene (1900–1968), Russian-born fashion photographer
• Paul Hoyningen-Huene (born 1946), German philosopher
• Huenes Marcelo Lemos (born 1981), Brazilian football player