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PPP2R1A

ยีนบนโครโมโซมของมนุษย์ 19

1B3U, 2IE3, 2IE4, 2NPP, 2NYL, 2NYM, 2PKG, 3C5W, 3DW8, 3K7V, 3K7W, 4I5L, 4I5N, 4LAC,%%s2IE4, 2NPP, 2IE3, 3K7V, 3K7W

PPP2R1A

PPP2R1A
Available structures
PDBOrtholog search: PDBeRCSB
Identifiers
AliasesPPP2R1A, PP2A-Aalpha, PP2AAALPHA, PR65A, MRD36, protein phosphatase 2 scaffold subunit Aalpha, PP2AA
External IDsOMIM: 605983; MGI: 1926334; HomoloGene: 68559; GeneCards: PPP2R1A; OMA:PPP2R1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5518

51792

Ensembl

ENSG00000105568

ENSMUSG00000007564

UniProt

P30153

Q76MZ3

RefSeq (mRNA)

NM_014225NM_001363656

NM_016891

RefSeq (protein)

NP_055040NP_001350585NP_055040.2

NP_058587

Location (UCSC)Chr 19: 52.19 – 52.23 MbChr 17: 21.17 – 21.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1Agene.[5] In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).[6]

Function

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.[7]

Role in human pathology

Mutations of the PPP2R1A gene cause Houge-Janssens syndrome-2, an intellectual developmental disorder.

Interactions

PPP2R1A has been shown to interact with:

Arabidopsis RCN1

RCN1 At1g25490 is one of three genes in Arabidopsis encoding Phosphoprotein Phosphatase 2A Regulatory Subunit A (PP2Aa). The association of different b subunits with a PP2Aa-PP2ac dimer is believed to determine substrate specificity.

Further reading

  • Zolnierowicz S (2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochem. Pharmacol. 60 (8): 1225–1235. doi:10.1016/S0006-2952(00)00424-X. PMID 11007961.
  • Walter G, Ruediger R, Slaughter C, Mumby M (1990). "Association of protein phosphatase 2A with polyoma virus medium tumor antigen". Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2521–2525. Bibcode:1990PNAS...87.2521W. doi:10.1073/pnas.87.7.2521. PMC 53721. PMID 2157202.
  • Hemmings BA, Adams-Pearson C, Maurer F, Mueller P, Goris J, Merlevede W, Hofsteenge J, Stone SR (1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure". Biochemistry. 29 (13): 3166–3173. doi:10.1021/bi00465a002. PMID 2159327.
  • Walter G, Ferre F, Espiritu O, Carbone-Wiley A (1989). "Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8669–8672. Bibcode:1989PNAS...86.8669W. doi:10.1073/pnas.86.22.8669. PMC 298349. PMID 2554323.
  • McCright B, Virshup DM (1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J. Biol. Chem. 270 (44): 26123–26128. doi:10.1074/jbc.270.44.26123. PMID 7592815.
  • Ruediger R, Hentz M, Fait J, Mumby M, Walter G (1994). "Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens". J. Virol. 68 (1): 123–9. doi:10.1128/JVI.68.1.123-129.1994. PMC 236271. PMID 8254721.
  • Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA (1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". Biochem. J. 317 (1): 187–94. doi:10.1042/bj3170187. PMC 1217462. PMID 8694763.
  • Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. Bibcode:1997FEBSL.401..197T. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886. S2CID 23293768.
  • Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–443. doi:10.1006/viro.1997.8873. PMID 9400615.
  • Ruediger R, Fields K, Walter G (1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens". J. Virol. 73 (1): 839–42. doi:10.1128/JVI.73.1.839-842.1999. PMC 103900. PMID 9847399.
  • Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D (1999). "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs". Cell. 96 (1): 99–110. doi:10.1016/S0092-8674(00)80963-0. PMID 9989501. S2CID 14465060.
  • Hong Y, Sarge KD (1999). "Regulation of protein phosphatase 2A activity by heat shock transcription factor 2". J. Biol. Chem. 274 (19): 12967–12970. doi:10.1074/jbc.274.19.12967. PMID 10224043.
  • Yan Z, Fedorov SA, Mumby MC, Williams RS (2000). "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Mol. Cell. Biol. 20 (3): 1021–1029. doi:10.1128/MCB.20.3.1021-1029.2000. PMC 85219. PMID 10629059.
  • Husi H, Ward MA, Choudhary JS, Choudhary JS, Blackstock WP (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci. 3 (7): 661–669. doi:10.1038/76615. hdl:1842/742. PMID 10862698. S2CID 14392630.
  • Ruteshouser EC, Ashworth LK, Huff V (2001). "Absence of PPP2R1A mutations in Wilms tumor". Oncogene. 20 (16): 2050–2054. doi:10.1038/sj.onc.1204301. PMID 11360189.
  • Lubert EJ, Hong Y, Sarge KD (2001). "Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5". J. Biol. Chem. 276 (42): 38582–38587. doi:10.1074/jbc.M106906200. PMID 11504734.
  • Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–370. doi:10.1006/viro.2001.1007. PMID 11531413.
  • Li X, Virshup DM (2002). "Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A". Eur. J. Biochem. 269 (2): 546–552. doi:10.1046/j.0014-2956.2001.02680.x. PMID 11856313.
Retrieved from "https://en.wikipedia.org/w/index.php?title=PPP2R1A&oldid=1318050249"

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ข้อมูลสำคัญจากบทความ

ข้อมูลสำคัญเกี่ยวกับ PPP2R1A

1B3U, 2IE3, 2IE4, 2NPP, 2NYL, 2NYM, 2PKG, 3C5W, 3DW8, 3K7V, 3K7W, 4I5L, 4I5N, 4LAC,%%s2IE4, 2NPP, 2IE3, 3K7V, 3K7W

Function

This gene encodes a constant regulatory subunit of protein phosphatase 2 . Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division.

Role in human pathology

Mutations of the PPP2R1A gene cause Houge-Janssens syndrome-2 , an intellectual developmental disorder.

Interactions

PPP2R1A has been shown to interact with: