Sign of Hertoghe
| Sign of Hertoghe | |
|---|---|
| Other names | Queen Anne's sign |
 | |
| Anne of Denmark mourning the death of her son Henry in 1612 | |
| Causes | Hypothyroidism, atopic dermatitis |
| Named after | Eugene Ludovic Christian Hertoghe |
The sign of Hertoghe or Queen Anne's sign is a type of madarosis, more specifically a thinning or loss of the outer third of the eyebrows, and may appear in severe hypothyroidism or atopic dermatitis.[1][2][3] It was also observed in lepromatous leprosy, secondary syphilis,[4][5]hypoparathyroidism,[6] poisoning with either lead or thallium, lupus, or normal aging.[7]
Name
The sign is named after the Belgian internist Eugene Ludovic Christian Hertoghe (April 5, 1860–January 3, 1928), who was a native of Antwerp, and was the first pioneer in thyroid function research.[2][3][8]
Queen Anne's sign
The association with Anne of Denmark is based on portraiture, although history does not suggest that she suffered an underactive thyroid.[9] The eponym is disputed by some,[10] though it has been suggested that Anne of France, Anne of Brittany, Anne of Austria, Anne Boleyn, and Anne of Cleves may all be eliminated as candidates.[11]