7-Fluorotryptamine

Clinical data
Other names	7-F-T; 7-Fluoro-T; 7-FT
Drug class	Serotonin receptor modulator; GPRC5Aagonist
ATC code	None
Identifiers
IUPAC name 2-(7-fluoro-1H-indol-3-yl)ethanamine
CAS Number	191927-74-9
PubChemCID	2769362
ChemSpider	2049887
ChEMBL	ChEMBL205229
CompTox Dashboard(EPA)	DTXSID90377692
ECHA InfoCard	100.197.219
Chemical and physical data
Formula	CHFN
Molar mass	178.210 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC2=C(C(=C1)F)NC=C2CCN
InChI InChI=1S/C10H11FN2/c11-9-3-1-2-8-7(4-5-12)6-13-10(8)9/h1-3,6,13H,4-5,12H2 Key:QRAWNNQNLQPNIZ-UHFFFAOYSA-N

7-Fluorotryptamine (7-FT) is a serotonin receptor modulator and weak GPRC5Aagonist of the tryptamine family.^[1][2] It is the 7-fluoroderivative of tryptamine.^[2] The drug is a low-potency agonist of the orphan receptor GPRC5A, with an ECTooltip half-maximal effective concentration of 7,200 nM.^[1][2][3] In addition to its GPRC5A agonism, 7-fluorotryptamine interacts with other receptors, such as the serotonin5-HT receptor.^[2] Derivatives of 7-fluorotryptamine have been described.^[4] 7-Fluorotryptamine was first described in the scientific literature by 1979.^[5] Its GPRC5A agonism was first described in 2023.^[2]

• Substituted tryptamine
• 7-Chlorotryptamine
• 7-Methyltryptamine
• 7-Hydroxytryptamine
• 7-F-5-MeO-MET
• 7-Chloro-AMT

• 7-ฟลูออโรทริปตามีน - การออกแบบไอโซเมอร์

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