ชาวอเมริกันเชื้อสายเม็กซิกันคือผู้ที่อาศัยอยู่ในสหรัฐอเมริกาและมี เชื้อสาย เม็กซิกันรายชื่อนี้รวมถึงผู้อพยพชาวเม็กซิกันและผู้ที่อาศัยอยู่ในภาคตะวันตกเฉียงใต้ของสหรัฐอเมริกาเมื่อครั้งที่ดินแดนดังกล่าวได้รับการผนวกเข้าเป็นส่วนหนึ่งของสหรัฐอเมริกาในปี 1848

• Gustavo Arellano (born 1979) – editor at the Los Angeles Times and writer/creator of ¡Ask a Mexican!
• Ron Arias (born 1941) – Chicano writer and correspondent
• Jim Avila – TV journalist and correspondent
• Ana Cabrera (born 1982) – television news anchor
• Ricardo Celis (born 1962) – Spanish language sportscaster
• María Antonieta Collins (born 1952) – TV host, journalist, and author
• Mandalit del Barco – award-winning art and culture reporter for National Public Radio
• Laura Diaz (born 1958) – Southern California newscaster and co-anchor of CBS 2 News
• Giselle Fernández (born 1961) – TV journalist and reporter
• Anselmo L. Figueroa (1861–1915) – journalist and political figure
• John Carlos Frey (born 1969) – investigative journalist
• Luis De La Garza (born 1954) – TV and radio host
• Christy Haubegger (born 1968) – movie producer and founder of Latina Magazine
• Maria Hinojosa (born 1961) – broadcast journalist and correspondent
• Monica C. Lozano (born 1956) – editor, publisher, and CEO of La Opinión, the largest Spanish language newspaper
• Rubén Martínez (writer) (born 1962) – award-winning journalist and author
• Tony Ortega (journalist) (born 1963) – newspaper editor, blogger
• Raul Peimbert (born 1962) – Spanish language TV journalist and newscaster
• John Quiñones (born 1952) – news correspondent, award-winning journalist
• Jorge Ramos (born 1958) – Spanish-language TV news anchor and journalist
• Naibe Reynoso (born 1973) – TV journalist and reporter
• Rubén Salazar (1928–1970) – TV journalist and reporter
• María Elena Salinas (born 1954) – Spanish language TV news anchor and journalist
• Lauren Sánchez (born 1969) – Emmy Award-winning journalist

• Anabel Abarca – former member of the Chicago City Council
• Oscar Zeta Acosta (1935–1974) – politician, attorney, minor novelist and activist
• Adrian Fontes (born 1970) – Secretary of State of Arizona
• Bob Archuleta (born 1945) – member of the California State Senate^[115]
• Katherine Archuleta (born 1949) – political executive
• Alexander Arvizu (born 1958) – United States Ambassador to Albania from 2010 to 2015
• Cisco Aguilar – Secretary of State of Nevada^[116]
• Pete Aguilar (born 1979) – U.S. representative from California (CA-31; CA-33|CA-33), former mayor of Redlands, California
• Amanda Aguirre (born 1953), former member of the Arizona Senate
• Mike Aguirre (born 1949) – former city attorney of San Diego, California
• Lucille Roybal-Allard (born 1941) – former U.S. representative from California (CA-33; CA-34; CA-40), former member of the California State Assembly
• Arturo Alonso (born 1999) – member of the Oklahoma House of Representatives
• Juan Bautista Alvarado (1809–1882) – twice governor of Alta California from 1836 to 1837 and 1838 to 1842
• Toney Anaya (born 1941) – former Governor of New Mexico and former Attorney General of New Mexico^[117]
• Rafael Anchia (born 1968) – member of the Texas House of Representatives
• Jerry Apodaca (1934-2023) – former Governor of New Mexico former Chair of the President's Council on Physical Fitness and Sports
• Jesse Arreguin (born 1984) – Mayor of Berkeley, California
• Ruben Ayala (1922–2012) – former member of the California Senate, former mayor of Chino, California^[118]
• Joe Baca (born 1947) – former U.S. Congressman from California and former member of both the California Senate and the California State Assembly
• Joe Baca Jr. (born 1969) – former California State Assembly member
• José Baca (1876–1924) – former Lieutenant Governor of New Mexico
• Polly Baca (born 1941) – served as Chair of the Democratic Caucus of the Colorado House of Representatives, former member of the Colorado Senate
• Hector Balderas (born 1973) – former Attorney General of New Mexico, former New Mexico State Auditor, and former member of the New Mexico House of Representatives
• Romana Acosta Bañuelos (1925–2018) – former Treasurer of the United States
• Nanette Barragán (born 1976) – U.S. representative from California (CA-44)
• Rosemary Barkett (born 1939) – former Chief Justice of the Florida Supreme Court, former Judge on the United States Court of Appeals for the Eleventh Circuit
• Xavier Becerra (born 1958) – Former United States Secretary of Health and Human Services, former Attorney General of California, former U.S. representative (CA-31), former California State Assembly member^[119]
• Gina M. Benavides (born 1962) – Justice at the Texas Thirteenth Court of Appeals
• Joseph Bernal (born 1927) – Texas State Representative
• Jaime Herrera Beutler (born 1978) – former U.S. Representative (WA-3), former member of the Washington House of Representatives
• Rosilicie Ochoa Bogh (born 1970) – member of the California Senate
• Henry Bonilla (born 1954) – former U.S. Congressman from Texas
• Susan Bonilla (born 1960) – former California State Assembly member, Contra Costa County, California Board of Supervisors member
• Flavio Bravo – member of the Arizona Senate^[120]
• Columba Bush (born 1953) – former First Lady of Florida
• George P. Bush (born 1976) – former Land Commissioner of Texas, son of Jeb Bush
• Albert Bustamante (1935–2021) – former U.S. Congressman from Texas
• Cruz Bustamante (born 1953) – former Lieutenant Governor of California, former Speaker of the California State Assembly^[121]
• Ezequiel Cabeza de Baca (1864–1917) – former Governor of New Mexico and former Lieutenant Governor of New Mexico
• Anna Escobedo Cabral (born 1959) – 42nd Treasurer of the United States
• Louis Caldera (born 1956) – former United States Secretary of the Army, former member of the California State Assembly
• Kiki Camarena (1947–1985) – undercover agent for the United States Drug Enforcement Administration
• Yadira Caraveo (born 1980) – former U.S. Congresswoman from Colorado (CO-8), former member of the Colorado House of Representatives
• Jovita Carranza (born 1949) – former Administrator of the Small Business Administration, former Deputy Administrator of the Small Business Administration, former Treasurer of the United States
• Quico Canseco (born 1949) – former U.S. representative from Texas
• Salud Carbajal (born 1964) – U.S. representative from California (CA-24)
• George Cardenas (born 1964) – member of the Cook County Board of Review, former member of the Chicago City Council
• Tony Cárdenas (born 1963) – former U.S. representative from California (CA-29), former member of the Los Angeles City Council, former California State Assembly member
• Carlos Antonio Carrillo (1783–1852) – Gobernador of Alta California, (1837–1838). His father, José Raimundo Carrillo, came from Loreto, Mexico
• José Antonio Carrillo (1796–1862) – Californio ranchero, official and politician; brother of Carlos Antonio Carrillo
• Juan Carrillo - member of the California State Assembly
• Juan José Carrillo (1842–1916) – first mayor of Santa Monica, California
• Greg Casar (born 1989) – U.S. representative from Texas (TX-35), former member of the Austin City Council
• Jose L. Castaneda – Member of the North Dakota House of Representatives
• Rubén Castillo (born 1954) – Chief Judge of the United States District Court for the Northern District of Illinois
• Carlos Cascos (born 1952) – former Secretary of State of Texas
• Joaquin Castro (born 1974) – United States Representative from Texas (TX-20), former member of the Texas House of Representatives
• José Castro (California, 1808 – February 1860) – acting governor of Alta California in 1835–1836, and Comandante General of the Mexican army in Alta California at the time of the 1846 Bear Flag Revolt and the Mexican–American War of 1846–1848
• Julian Castro (born 1974) – Former Mayor of San Antonio, former U.S. Secretary of Housing and Urban Development, former member of the San Antonio City Council and 2020 U.S. presidential candidate
• Raul Hector Castro (1916–2015) – former Governor of Arizona, former U.S. ambassador to Argentina, Bolivia, and El Salvador
• Lauro Cavazos (1927–2022) – United States Secretary of Education^[122]
• Gabe Cazares (1920–2006) – former mayor of Clearwater, Florida
• Cesar Chavez (born 1987) – former member of the Arizona House of Representatives
• Dennis Chavez (1888–1962) – U.S. Senator and Congressman from New Mexico^[123]
• Tibo J. Chávez (1912–1991) – former Lieutenant Governor of New Mexico and member of the New Mexico Senate
• Juan Ciscomani (born 1982) – U.S. representative from Arizona (AZ-6)
• Gil Cisneros (born 1971) – U.S. Congressman from California (CA-39; CA-31), former Under Secretary of Defense for Personnel and Readiness
• Henry Cisneros (born 1947) – former Secretary of Housing and Urban Development and mayor of San Antonio, Texas^[124]
• Mark Cisneros – member of the Iowa House of Representatives
• Bob Coffin – former member of both the Nevada Senate and the Nevada Assembly
• Frank Coombs (1853–1934) – former U.S. congressman from California, former US ambassador to Japan, former Speaker of the California State Assembly^[125]
• Patty Contreras – member of the Arizona House of Representatives^[126]
• Antonio F. Coronel – former mayor of Los Angeles, former Los Angeles County Assessor, former California State Treasurer
• Lou Correa (born 1958) – U.S. representative from California (CA-46), former member of both the California Senate and the California State Assembly, and former member of the Orange County Board of Supervisors
• Catherine Cortez Masto (born 1964) – U.S. Senator from Nevada, former Nevada Attorney General
• Joe Coto (born 1939) – member of the California State Assembly
• Jose Cruz (Oklahoma politician) – former member of the Oklahoma House of Representatives
• Monica De La Cruz (born 1975) – U.S. representative from Texas (TX-15)
• Ruth Cruz (born 1983 or 1984) – member of the Chicago City Council
• Henry Cuellar (born 1955) – U.S. House of Representatives Texas's 28th congressional district, former Secretary of State of Texas, former member of the Texas House of Representatives
• Mariano-Florentino Cuéllar (born 1972) – former associate justice of the Supreme Court of California
• Mike Curb (born 1944) – former Lieutenant Governor of California
• Gonzalo P. Curiel (born 1953) – judge of the United States District Court for the Southern District of California
• Alessandro Cutrona – member of the Ohio House of Representatives
• Billy Dalto (born 1976) – former ember of the Oregon House of Representatives
• James DeAnda (1925–2006) – former judge of the United States District Court for the Southern District of Texas, attorney, noted for his activities in defense of Hispanic civil rights, particularly as a plaintiff's attorney in Hernandez v. Texas.
• Ignacio De La Fuente (born 1949) – former Vice Mayor of Oakland, member of the Oakland City Council
• Pablo de la Guerra (1819–1874) – former acting Lieutenant Governor of California member of the California State Senate
• Antonio Delgado – Lieutenant Governor of New York, former U.S. congressman from New York (NY-19)
• Ygnacio del Valle (1808–1880) – member of the Los Angeles Common Council (1852, 1856), California State Assemblyman (1852–1853), Mayor of Los Angeles (1850)
• Lori Chavez-DeRemer (born 1968) – former U.S. Secretary of Labor, former U.S. Congresswoman from Oregon (OR-5), former mayor of Happy Valley, Oregon
• Leonora Dodge – state legislator in Vermont
• Rosalba Dominguez – state legislator in Utah
• Elena J. Duarte (born 1966) – Associate Justice of the California Court of Appeal
• Maria Elena Durazo (born 1953) – member of the California Senate
• Luz Escamilla (born 1978) – member of the Utah Senate
• Veronica Escobar (born 1969) – U.S. representatives from Texas (TX-16)
• Gabe Evans - U.S. Congressman from Colorado (CO-8); former member of the Colorado House of Representatives
• Antonio M. Fernandez (1902-1956) – Former U.S. Congressman from New Mexico
• Ben Fernandez (1925–2000) – American politician, financial consultant and special ambassador. He was a member of the Republican Party. He ran for President of the United States in 1980, 1984 and 1988, making him America's first major-party presidential contender of Hispanic origin
• Teresa Leger Fernandez (born 1959) – U.S. representative from New Mexico (NM-3)
• Marco Antonio Firebaugh (1966-2006) – former California State Assembly member
• Edgar Flores (politician) (born 1986) – member of the Nevada Senate, and former member of the Nevada Assembly
• Mayra Flores (born 1986) – former U.S. representative from Texas (TX-34)
• Soñia Galaviz – member of the Idaho House of Representatives
• Mario Gallegos Jr. (1950–2012) – former member of both the Texas Senate and the Texas House of Representatives
• Pete Gallego (born 1961) – former U.S. representative (TX-23), former member of the Texas House of Representatives
• Ruben Gallego (born 1979) – U.S. Senator from Arizona, former U.S. representative (AZ-7), former member of the Arizona House of Representatives
• Tony Gallegos (1924–2018) – Chairman of the Equal Employment Opportunity Commission
• Cristina Garcia – former California State Assembly member
• Joseph Garcia (born 1957) – former Lieutenant Governor of Colorado
• Jesus "Chuy" Garcia (born 1956) – U.S. representative from Illinois (IL-4), former member of the Cook County Board of Commissioners, former member of Illinois Senate, former member of the Chicago City Council, Mayoral Candidate for the city of Chicago
• Jorge Luis Garcia (1953–2010), former member of the Arizona Senate
• Mike Garcia (born 1976) – former U.S. Congressman from California (CA-25; CA-27)
• Sylvia Garcia (born 1950) – U.S. representative from Texas (TX-29), former member of the Texas Senate
• Ruben Garcia Jr. (born 1951) – former executive assistant director of FBI
• Eric Garcetti (born 1971) – U.S. Ambassador to India, former Mayor of Los Angeles, former President of the Los Angeles City Council
• Gil Garcetti (born 1941) – former Los Angeles County District Attorney
• Edward D. Garza (born 1969) – former mayor San Antonio, Texas and former member of the San Antonio City Council
• Margarito C. Garza (1931–1995) – district judge, comic book creator
• Antonio María de la Guerra (1825–1891) – Mayor of Santa Barbara, California (1856–1858, 1859–1864), California state senator
• José Antonio de la Garza (1776–1851?) – Mayor of San Antonio, Texas (in 1813 and 1832), the first landowner in San Antonio and the first man to create a coin in this state.
• Kika de la Garza (1927-2017) – former U.S. Congressman from Texas, former member of the Texas House of Representatives
• Reynaldo Guerra Garza (1915–2004) – first Hispanic judge appointed to the U.S. Court of Appeals (Fifth Circuit), former judge on the United States District Court for the Southern District of Texas
• Tony Garza (born 1959) – former U.S. Ambassador to Mexico, former Secretary of State of Texas, former member of the Texas Railroad Commission
• Victor Gordo (born 1969) – Mayor of Pasadena, California
• Jimmy Gomez (born 1974) – U.S. representative from California (CA-34), former California State Assembly member
• Alberto Gonzales (born 1955) – former United States Attorney General, former White House Counsel, former justice on the Supreme Court of Texas, former Secretary of State of Texas
• Rafael Gonzales (1789–1857) – native of San Antonio, Texas, he was governor of Coahuila and Texas.
• Ron Gonzales (born 1951) – former mayor of San José, California^[127]
• Tony Gonzales (born 1980) – former U.S. representative from Texas (TX-23)
• Cecelia González – member of the Nevada Assembly
• Charlie Gonzalez (born 1945) – former U.S. representative (Texas)
• Edgar Gonzalez Jr. (born 1996) – member of the Illinois House of Representatives
• Henry Gonzalez (1916–2000) – former U.S. representative (Texas)^[128]
• Irma Elsa Gonzalez (born 1948) – former judge of the United States District Court for the Southern District of California
• Lena Gonzalez (born 1981) – member of the California Senate
• Matt Gonzalez (born 1965) – former President of the San Francisco Board of Supervisors
• Ramon Gonzalez Jr. (born 1947) – former member of the Kansas House of Representatives
• Steven Gonzalez (born 1963) – Chief Justice of the Washington Supreme Court
• Vicente Gonzalez (born 1967) – U.S. representative from Texas (TX-15; TX-34)
• Adelita Grijalva (born 1970) – U.S. representative (AZ-7), former Pima County Board of Supervisors
• Raúl Grijalva (1948–2025)^[129] – Former U.S. representative (AZ-3; AZ-7)
• Michelle Lujan Grisham (born 1959) – Governor of New Mexico and former U.S. representative (NM-1)
• Patricia Guerrero (born 1971) – Chief Justice of California, former Associate Justice of the California Supreme Court, former Associate Justice of the California Court of Appeal, former Judge of the San Diego County Superior Court
• Yanira Gurrola, member of the New Mexico House of Representatives
• Jeylú Gutiérrez (born 1987/1988) – member of the Chicago City Council
• Philip S. Gutierrez (born 1959) – judge of the United States District Court for the Central District of California
• Eva Guzman (born 1961) – former member of the Supreme Court of Texas
• Isabel Guzman (born 1970 or 1971) – Administrator of the Small Business Administration
• Lucía Guzmán (born 1945) – former member of the Colorado Senate
• Ana Hernandez (born 1978) - member of the Texas House of Representatives
• Benigno C. Hernandez (1862–1954) – former Congressman from New Mexico
• Eunisses Hernandez (born 1990) – member of the Los Angeles City Council
• Melody Hernandez – member of the Arizona House of Representatives^[130]
• Norma Hernandez – member of the Illinois House of Representatives
• Roger Hernández (born 1975) – former mayor of West Covina, California, former California State Assembly member
• Tim Hernández (born 1997) - member of the Colorado House of Representatives
• Ruben Hinojosa (born 1940) – former U.S. representative from Texas (TX-15)
• Ben Hueso (born 1969) – former member of both the California Senate and the California State Assembly, former member of the San Diego City Council
• Jose Huizar (born 1968) – former member of the Los Angeles City Council
• Lilian Jiménez – member of the Illinois House of Representatives
• Michael Brooks-Jimenez – member of the Oklahoma Senate
• Debora Juarez – former president of the Seattle City Council
• Ruben Kihuen (born 1980) – former U.S. representative from Nevada (NV-4), former member of both the Nevada Senate and the Nevada Assembly
• Ricardo Lara (born 1977) – California Insurance Commissioner, former member of both the California Senate and the California State Assembly
• Octaviano Ambrosio Larrazolo (1859–1930) – former Governor of New Mexico and first Latino to serve United States Senate
• Idalia Lechuga-Tena – former member of the New Mexico House of Representatives
• Oscar Leeser (born 1958) – Mayor of El Paso (2013–2017, 2021–2025)
• Teresa Alonso Leon (born 1975) – former member of the Oregon House of Representatives
• Mike Levin (born 1978) – U.S. Representative from California (CA-49)
• Sam Liccardo (born 1970) – U.S. representative from California (CA-16), former mayor of San Jose, California and former member of the San Jose City Council
• Kevin Lincoln (born 1980) – mayor of Stockton, California^[131]
• Carmen Lomellin (born 1950) – former U.S. ambassador to the Organization of American States
• Greg Lopez (born 1964) – former U.S. Congressman from Colorado (CO-4)
• Janie Lopez – member of the Texas House of Representatives
• Marco A. López Jr. (born 1978) – Chief of Staff of U.S. Customs and Border Protection (2009–2011), Director of the Arizona Department of Commerce (2008–2009), Mayor of Nogales, Arizona (2001–2004)
• Patty López (born 1968) – member of the San Fernando, California City Council, former member of the California State Assembly
• Anthony Loubet – member of the Utah House of Representatives
• J. M. Lozano (born 1980) – member of the Texas House of Representatives
• Eric Lucero (born 1977 or 1978) – member of the Minnesota Senate, former member of the Minnesota House of Representatives
• Ben Ray Lujan (born 1972) – U.S. Senator from New Mexico, former U.S. representative from New Mexico (NM-3)^[132]
• Manuel Lujan Jr. (1928–2019) – U.S. representative from New Mexico^[133]
• Anna Paulina Luna (born 1989) – first Mexican-American U.S. representative from Florida (FL-13)
• Casey Luna (born 1931) – former Lieutenant Governor of New Mexico
• Roberto de la Madrid (1922–2010) – governor of Baja California
• Abel Maldonado (born 1967) – 47th Lieutenant Governor of California, former member of both the California Senate and the California State Assembly
• Rosario Marin (born 1958) – 41st Treasurer of the United States, former mayor of Huntington Park, California
• Marina Marmolejo (born 1971) – judge of the United States District Court for the Southern District of Texas
• Catherine Cortez Masto (born 1964) – U.S. Senator from Nevada, former Attorney General of Nevada
• Diane Martinez (born 1953) – former member of the California State Assembly
• Hugo Soto-Martinez – member of the Los Angeles City Council
• Matthew G. Martinez (1929–2011) – former U.S. Congressman from California, former member of the California State Assembly
• Nury Martinez (born 1973) – former President of the Los Angeles City Council
• Susana Martinez (born 1959) – former governor of New Mexico
• Brian Mast (born 1980) – U.S. representative (FL-18; FL-21)
• Gloria Negrete McLeod (born 1941) – former U.S. Congresswoman from California, former member of both the California Senate and the California State Assembly
• Harold Medina (1888–1990) – Senior Judge of United States Court of Appeals for the Second Circuit, former judge of the United States District Court for the Southern District of New York
• Carlos Menchaca (born 1980) – former member of the New York City Council
• Susana Mendoza (born 1972) – Illinois Comptroller, former City Clerk of Chicago, and former member of the Illinois House of Representatives.
• Ken Miyagishima – mayor of Las Cruces, New Mexico
• Gloria Molina (1948-2023) – former Chair of Los Angeles County, former member of the California State Assembly, former vice-chair of the Democratic National Committee^[134]
• Roberto Mondragón (born 1940) – former Lieutenant Governor of New Mexico
• Cindy Montañez (1974-2023) – former member of the California State Assembly
• Joseph Montoya (1915–1978) – former U.S. Senator and Congressman from New Mexico, former Lieutenant Governor of New Mexico, former member of both the New Mexico Senate and the New Mexico House of Representatives^[135]
• Nestor Montoya (1862–1923) – former Congressman from New Mexico
• David Sánchez Morales (1925–1978) – CIA operative
• Eddie Morales (born 1975) – member of the Texas House of Representatives
• Howie Morales (born 1973) – Lieutenant Governor of New Mexico, former member of the New Mexico Senate
• Carlos R. Moreno (born 1948) – former justice on the California Supreme Court, former US ambassador to Belize, former judge of the United States District Court for the Central District of California
• Helena Moreno (born 1977) – mayor of New Orleans; former member of the New Orleans City Council, former president of the New Orleans City Council, former member of the Louisiana House of Representatives
• Ramiro Muñiz, known as Ramsey Muñiz (1942–2022) – first Hispanic whose name appeared on a Texas gubernatorialgeneral electionballot, in 1972 and 1974, each time as the nominee of the Raza Unida Party but lost both elections.^[136]
• Ricardo Muñoz (born 1965) – former member of the Chicago City Council
• Carlos Murguia (born 1957) – former judge of the United States District Court for the District of Kansas
• Mary H. Murguia (born 1960) – Judge of the United States Court of Appeals for the Ninth Circuit, former judge of the United States District Court for the District of Arizona
• Ramón Músquiz (1797–1867) – Governor of Coahuila and Texas from 1830 to 1831 and in 1835
• Grace Napolitano (born 1936) – former U.S. representative (CA-31), former member of the California State Assembly
• Cindy Nava, member of the New Mexico Senate
• Julian Nava (1927–2022) – former U.S. Ambassador to Mexico
• Pedro Nava (born 1948) – former member of the California State Assembly
• Fabian Núñez (born 1966) – former Speaker of the California State Assembly^[137]
• Estevan Ochoa (1831–1888) – historic mayor of Tucson, Arizona, he was the first Mexican-American mayor after the Gadsden Purchase of 1854 ^[138]
• Richard Ojeda (born 1970) – former member of the West Virginia Senate
• Fernando M. Olguin (born 1961) – Judge of the United States District Court for the Central District of California
• Darleen Ortega (born 1962) – Judge on the Oregon Court of Appeals
• Liz Ortega (born 1977) – member of the California State Assembly
• Katherine D. Ortega (born 1934) – 38th Treasurer of the United States
• Aaron Ortiz (born 1991) – member of the Illinois House of Representatives
• Solomon Ortiz (born 1937) – former U.S. representative (TX-27)^[139]
• Mariano S. Otero (1844–1904) – Delegate from the Territory of New Mexico
• Miguel Antonio Otero (1859–1944) – former Governor of New Mexico
• Rolando Pablos (born 1967) – former Secretary of State of Texas
• Nick Pacheco (born 1964) – former member of the Los Angeles City Council
• Romualdo Pacheco (1831–1899) – former Governor of California, former Lieutenant Governor of California, former California State Treasurer, former US congressman, former US ambassador to Costa Rica, El Salvador, Guatemala, Honduras, and Nicaragua
• Alex Padilla (born 1973) – U.S. Senator from California, former Secretary of State of California, former President of the Los Angeles City Council
• Imelda Padilla (born 1987) – member of the Los Angeles City Council
• Mike Padilla (born 1948/1949) – mayor of Topeka, Kansas
• Steve Padilla (born 1967) – member of the California Senate, former mayor of Chula Vista, California
• Richard Paez (born 1947) – federal judge on the United States Court of Appeals for the Ninth Circuit, former judge of the United States District Court for the Central District of California
• Veronica Paiz – member of the Michigan House of Representatives
• Ed Pastor (1943–2018) – former U.S. representative from Arizona (AZ-2; AZ-4; AZ-7)
• Federico Peña (born 1947) – former mayor of Denver, Colorado, former United States Secretary of Transportation, former United States Secretary of Energy, former member of the Colorado House of Representatives
• Francisco Perea (1830–1913) – Delegate from the Territory of New Mexico
• Marie Gluesenkamp Perez (born 1988) – U.S. representative from Washington (WA-3)
• Andrés Pico (1810–February 14, 1876) – mixed-race Californio youth; a successful rancher and commander; former member of both the California Senate and the California State Assembly; in 19th century California; brother of Pío Pico
• Pío Pico (May 5, 1801 – September 11, 1894) – last Governor of Alta California (now the State of California) under Mexican rule
• Margarita Prentice (1931–2019) – former member of the Washington Senate and the Washington House of Representatives
• Miguel A. Pulido (born 1956) – Mayor of Santa Ana, California (1994–2020)
• Marcelino Quiñonez – former member of the Arizona House of Representatives
• Ceferino Quintana – former Lieutenant Governor of New Mexico
• Robert Ramirez – former member of the Colorado House of Representatives
• Carlos Ramirez-Rosa (born 1989) – member of the Chicago City Council^[140]
• Emily Randall (born 1985) – U.S. representative from Washington (WA-6), former member of the Washington Senate
• Irma Lerma Rangel (1931–2003) – former member of the Texas House of Representatives
• Jose Maria Redondo (1830–1878) – Mayor of Yuma, Arizona (1878)
• Anthony Rendon (born 1968) – former Speaker of the California State Assembly
• Ben Reyes (born 1947) – former member of the Texas House of Representatives and the Houston City Council
• Silvestre Reyes (born 1944) – former U.S. Congressman from Texas
• Cruz Reynoso (1931–2021) – judge on the Supreme Court of California, Presidential Medal of Freedom (recipient)
• Bill Richardson (1947-2023) – former Governor of New Mexico, former United States Ambassador to the United Nations, former United States Secretary of Energy, former U.S. Congressman from New Mexico^[141]
• Rebecca Rios (born 1967) – former member of both the Arizona Senate (served as minority leader) and the Arizona House of Representatives
• Rosa Rios (born 1965) – 43rd Treasurer of the United States, businesswoman, executive and entrepreneur.
• Luz Rivas (born 1974) – U.S. representative from California (CA-29); former member of the California State Assembly
• Albert Robles – former mayor of Carson, California and convicted criminal
• Ciro Rodriguez (born 1946) – former U.S. Congressman from Texas, former member of the Texas House of Representatives
• Regina M. Rodriguez (born 1963) – Judge of the United States District Court for the District of Colorado
• Angela Romero - minority leader and member of the Utah House of Representatives
• Brenda Lopez Romero - former member of the Georgia House of Representatives
• Gloria Romero (born 1955) – former member of both the California Senate (served as majority leader) and the California State Assembly. He was brother of Pío Pico, college professor
• Regina Romero (born 1974) – Mayor of Tucson, Arizona
• Trinidad Romero (1835–1918) – Delegate to United States Congress from the Territory of New Mexico
• Edward Roybal (1916–2005) – former U.S. representative from California (CA-30; CA-25), former member of the Los Angeles City Council^[142]
• Blanca Rubio (born 1969) – member of the California State Assembly
• Carmen Rubio – Portland City Commissioner
• Susan Rubio (born 1970) – member of the California Senate
• Ernesto Ruffo Appel (born 1952) – politician and former governor of Baja California
• Raul Ruiz (born 1972) – U.S. representative from California (CA-36; CA-25)
• Mary Salas (born 1948) – former mayor of Chula Vista, California, former member of the California State Assembly
• John Salazar (born 1953) – U.S. representative from Colorado (CO-3), former member of the Colorado House of Representatives
• Ken Salazar (born 1955) – Former U.S. Ambassador to Mexico, former United States Secretary of the Interior, former U.S. Senator (CO), former Colorado Attorney General
• Athena Salman (born 1989) – former member of the Arizona House of Representatives^[143]
• John Sanchez (born 1963) – former Lieutenant Governor of New Mexico and member of the New Mexico House of Representatives
• Loretta Sanchez (born 1960) – U.S. representative from Califronia (CA-47)^[144]
• Linda Sánchez (born 1969) – U.S. representative (CA-39; CA-38)^[145]
• Brian Sandoval (born 1963) – former Governor of Nevada, former Attorney General of Nevada, former judge of the United States District Court for the District of Nevada, former chair of the Nevada Gaming Commission, and former member of the Nevada Assembly^[146]
• Gerardo Sandoval (born 1962) – judge of the Superior Court of California
• Mariana Sandoval – member of the Arizona House of Representatives^[147]
• Andrea Salinas (born 1969) – U.S. representative from Oregon (OR-6), former member of the Oregon House of Representatives
• Simon Salinas (born 1955) – former member of the California State Assembly
• Oscar De Los Santos – member of the Arizona House of Representatives
• Xochitl Torres Small (born 1984) – former United States Deputy Secretary of Agriculture, former Under Secretary of Agriculture for Rural Development, former US representative from New Mexico (NM-2)
• Daniel Solis (born 1949) – former member of the Chicago City Council
• Hilda Solis (born 1957) – U.S. Secretary of Labor, former U.S. representative from California (CA-31; CA-32), former Chair of Los Angeles County, former member of both the California Senate and the California State Assembly^[148]
• Jose Solorio (born 1970) – former member of the Santa Ana, California City Council, former member of the California State Assembly
• Esmeralda Soria (born 1982) – member of the California State Assembly
• Thomas M. Storke (1876–1971) – former U.S. Senator from California^[149]
• Frank Tejeda (1945–1997) – former U.S. Congressman from Texas, former member of both the Texas Senate and the Texas House of Representatives
• Cynthia Telles – U.S. Ambassador to Costa Rica
• Raymond Telles (1915–2013) – first mayor of a large American city (El Paso, Texas), former US ambassador to Costa Rica
• Hector De La Torre (born 1967) – former member of the California State Assembly
• Esteban Edward Torres (1930–2022) – former U.S. Representative from California, former U.S. ambassador to UNESCO, and labor activist^[150]
• Ken Trujillo – former candidate for mayor of Philadelphia. He created largest not for profit serving Hispanic community in Philadelphia, The Congreso, which is now one of the largest anti-poverty advocates in the nation and served Philadelphia as City Solicitor and an Assistant U.S. Attorney.^[151]
• Abelardo L. Valdez – diplomat and lawyer, President and Vice Chair of the Council of American Ambassadors
• Lupe Valdez (born 1947) – former Sheriff of Dallas County
• Anna M. Valencia (born 1985) – City Clerk of Chicago
• Avelino Valencia (born 1988) – member of the California State Assembly
• Judith Valles (born 1933) – former mayor of San Bernardino, California
• Juan Vargas (born 1961) – U.S. representative from California (CA-51; CA-52), former member of both the California Senate and the California State Assembly, former member of the San Diego City Council
• Nora Vargas (born 1971) – former Chair of the San Diego County Board of Supervisors
• Gabe Vasquez (born 1984) – U.S. Congressman from New Mexico (NM-2); former member of the Las Cruces, New Mexico City Council
• Gaddi Vasquez (born 1955) – U.S. Ambassador and 8th United States representative to the United NationsFood and Agriculture Organization, former member of the Orange County Board of Supervisors
• Martha Vázquez (born 1953) – judge of the United States District Court for the District of New Mexico
• Blanca Vela (1936–2014) – former mayor of Brownsville, Texas
• Filemon Vela Jr. (born 1963) – former U.S. representative (TX-34)
• Andrew Velasquez (born 1969) – Regional Administrator for the U.S. Department of Homeland Security's Federal Emergency Management Agency (FEMA)
• Antonio Villaraigosa (born 1953) – former Mayor of Los Angeles, former member of the Los Angeles City Council, former Speaker of the California State Assembly^[152]
• Barbara Vucanovich (1921–2013) – American Republican politician. She was the first Latino American to serve in the House of Representatives, representing Nevada.
• Kim McLane Wardlaw (born 1954) – judge of the United States Court of Appeals for the Ninth Circuit, former United States District Court for the Central District of California
• Joe Wardy (born 1953) – former mayor of El Paso, Texas
• Mary Yu (born 1957) – associate justice of the Washington Supreme Court
• Judith Zaffirini (born 1946) – member of the Texas Senate
• Juan Carlos Zarate – former Assistant Secretary of the Treasury for Terrorist Financing

• Anthony Acevedo (1924–2018) – soldier during World War II whose diary was instrumental in documenting Nazi atrocities.
• Bertrand Blanchard Acosta (1895–1954) – aviator, fighter pilot
• Lucian Adams (1922–2003) – Medal of Honor (World War II)
• Michael J. Aguilar (born 1950) – Marine Corps brigadier general
• Everett Alvarez Jr. (born 1937) – Navy LCdr/pilot who endured 8.5 years in Vietnamese captivity and one of the longest periods as a U.S. prisoner of war (POW)
• Cipriano Andrade (1840–1911) – served in the United States Navy for forty years
• Juan G. Ayala – two-star General in the U.S. Marine Corps and former Commander of the Marine Corps Installations Command
• Joe R. Baldonado (1930–1950) – Medal of Honor (Korean War)
• David B. Barkley (1899–1918) – Medal of Honor (World War I)
• Roy Benavidez (1935–1998) – Medal of Honor (Vietnam War)
• Pedro Cano (1920–1952) – Medal of Honor (World War II)
• Robert Cardenas (1920–2022) – U.S. Air Forcebrigadier general
• Richard E. Cavazos (1929–2017) – first U.S. Army Hispanic 4-star general, Distinguished Service Cross (Korea and Vietnam)
• Manuel Antonio Chaves (1818? – 1889) – soldier in the Mexican Army and rancher in New Mexico
• Kathlene Contres (born 1955) – U.S. Navy
• Emilio A. De La Garza (1949–1970) – Medal of Honor (Vietnam War)
• Jesus S. Duran (1948–1977) – Medal of Honor (Vietnam War)
• Victor H. Espinoza (1929–1986) – Medal of Honor (Korean War)
• Santiago J. Erevia (1946–2016) – Medal of Honor (Vietnam War)
• Daniel Fernandez (1944–1966) – Medal of Honor (Vietnam War)
• José María Flores (1818–1866) – General and Governor of Alta California (Mexican–American War)
• Guy Gabaldon (1926–2006) – Navy Cross recipient, credited with capturing (or persuading to surrender) about 1,500 Japanese soldiers and civilians during the Battle of Saipan (World War II)
• Joe Gandara (1924–1944) – Medal of Honor (World War II)
• Candelario Garcia (1944–2013) – Medal of Honor (Vietnam War)
• Marcario Garcia (1920–1972) – Medal of Honor (World War II)
• Edward Gomez (1932–1951) – Medal of Honor (Korean War)
• Eduardo C. Gomez (1919–1972) – Medal of Honor (Korean War)
• Harold Gonsalves (1926–1945) – Medal of Honor (World War II)
• David M. Gonzales (1923–1945) – Medal of Honor (World War II)
• Alfredo Cantu "Freddy" Gonzalez (1946–1968) – Medal of Honor, KIA in Huế (Vietnam)
• Ambrosio Guillen (1929–1953) – Medal of Honor (Korean War)
• Rodolfo P. Hernandez (1931–2013) – Medal of Honor (Korean War)
• Silvestre S. Herrera (1917–2007) – Medal of Honor (World War II)
• Edward Hidalgo (1912–1995) – former Secretary of the Navy
• Jose F. Jimenez (1946–1969) – Medal of Honor (Vietnam)
• Miguel Keith (1951–1970) – Medal of Honor (Vietnam)
• Salvador J. Lara (1920–1945) – Medal of Honor (World War II)
• Felix Z. Longoria Jr. (1920–1945) – first Mexican American buried in Arlington National Cemetery (World War II)
• Jose M. Lopez (1910–2005) – Medal of Honor (World War II)
• Benito Martinez (1932–1952) – Medal of Honor (Korean War)
• Joe P. Martinez (1920–1943) – Medal of Honor (World War II)
• Joseph V. Medina (born 1953) – Brigadier General
• Louis Gonzaga Mendez Jr. (1915–2001) – highly decorated colonel, commander of the 3rd Battalion, 508th Parachute Infantry Regiment (World War II). He was born in Mexico.
• Tony Mendez (1940–2019) – ex-CIA agent, portrayed in 2012 American film Argo.^[153]
• Ernest Medina (1936–2018) – Captain of Company C, 1st Battalion, 20th Infantry of the 11th Brigade, Americal Division
• Manuel V. Mendoza (1922–2001) – Medal of Honor (World War II and Korean War)
• Eugene A. Obregon (1930–1950) – Medal of Honor (Korean War)
• Ralph Ambrose O'Neill (1896–1980) – flying ace during WWI
• Mike C. Pena (1924–1950) – Medal of Honor (World War II and Korean War)
• Rafael Peralta (1979–2004) – Navy Cross (Iraq War)
• Oscar F. Perdomo (1919–1976) – United States Air Forceflying ace (World War II)
• Manuel Perez Jr. (1923–1945) – Medal of Honor (World War II)
• Leroy Petry (born 1979) – Medal of Honor (War in Afghanistan)
• Lori Piestewa (1973–2003) – first woman in the U.S. armed forces killed in the 2003 Iraq war^[154]
• Alfred V. Rascon (born 1945) – Medal of Honor (Vietnam War)
• Eldon Regua (born 1955) – Major General in the US Army reserve
• Louis R. Rocco (1938–2002) – Medal of Honor (Vietnam War)
• Jose Rodela (born 1937) – Medal of Honor (Vietnam War)
• Cleto Rodriguez (1923–1990) – Medal of Honor (World War II)
• Joseph C. Rodriguez (1928–2005) – Medal of Honor (Korean War)
• Alejandro R. Ruiz (1923–2009) – Medal of Honor (World War II)
• Ricardo Sanchez (born 1953) – United States Army General and author (Iraq War)
• Marcelino Serna (1896–1992) – Distinguished Service Cross (World War I)
• France Silva (1876–1951) – Medal of Honor (boxer Rebellion)^[155]
• Alberto Valdés (1918-1998) - Good Conduct Medal, American Campaign Medal and European African Middle Eastern Campaign Medal (World War II)
• Jose F. Valdez (1925–1945) – Medal of Honor (World War II)
• Eugene A. Valencia Jr. (1921–1972) – flying ace (World War II), Navy Cross
• Alfred Valenzuela (born 1948) – major general, United States Army
• Jay R. Vargas (born 1938) – Medal of Honor (Vietnam)
• Ysmael R. Villegas (1924–1945) – Medal of Honor (World War II)
• Maximo Yabes (1932–1967) – Medal of Honor (Vietnam)
• Sam Ybarra (1945–1982) – United States Army soldier who served in the Tiger Force commando unit attached to the 101st Airborne Division during the Vietnam War. He was of Mexican and Apache descent.

• 2Slimey (born 2006) - Rapper and songwriter
• Ana Victoria (born 1983) - Singer-songwriter, daughter of the Mexicans Diego Verdaguer and Amanda Miguel
• Ángela Aguilar (born 2003) - Singer, daughter of Pepe Aguilar
• Ashley Grace (born 1987) - Singer-songwriter and activist, co-founder of the Mexican-American music duo, Ha*Ash
• Addison Rae (born 2000), Singer and actress
• Becky G (born 1997) - Singer and actress
• Camila Cabello (born 1997) - Singer-songwriter, former member of Fifth Harmony
• Carlos Santana (born 1947) - Guitarist and founding member of Santana
• David Hidalgo (born 1954) - Guitarist, founding member of the Chicano rock band, Los Lobos
• Gerardo Ortiz (born 1989) - Regional Mexican music singer
• Hanna Nicole (born 1985) - Singer-songwriter and producer, co-founder member of the Mexican-American music duo, Ha*Ash
• Joan Baez (born 1941) - Singer-songwriter and activist
• Omar Apollo (born 1997) - Singer and composer
• Pepe Aguilar (born 1968) - Singer and composer, son of the Mexican singers and actors Antonio Aguilar and Flor Silvestre
• Ritchie Valens (1941-1959) - Singer and rock and roll pioneer
• Selena (1971-1995) - Tejano singer, called queen of Texan music
• Selena Gomez (born 1992) - Singer-songwriter, her song "Lose You To Love Me" reached the top of the Billboard Hot 100
• Tekashi 69 (born 1996) - Rapper and composer, his song "Trollz" with rapper Nicki Minaj reached the top of the Billboard Hot 100

• Rodolfo Acuña (born 1932) – historian and professor
• Ricardo Ainslie – psychology professor
• Norma Alarcón (born 1943) – author, professor, and publisher
• Frederick Luis Aldama (born 1969) – university distinguished scholar, writer
• Lena Lovato Archuleta (1920–2011) – educator, librarian, and administrator
• Alfred Arteaga (1950–2008) – writer, poet, and scholar
• Deborah Berebichez – physicist, data scientist, and educator
• Martha E. Bernal (1931–2001) – clinical psychologist
• Elsa Salazar Cade (born 1952) – entomologist/science educator
• Mariano Velazquez de la Cadena (1778–1860) – grammarian, scholar, and author
• Nínive Clements Calegari (born 1971) – educator, founder of national literacy program, 826 National, and The Teacher Salary Project.
• Erika Tatiana Camacho (born 1974) – mathematical biologist
• Jimena Canales (born 1973) – physicist and engineer, and award-winning historian of science
• Richard Carranza – Chancellor, New York CityPublic Schools, appointed in March 2018^[156]
• David Carrasco (born 1944) – historian of religion, anthropologist, and Mesoamericanist scholar
• Oscar Casares (born 1964) – author and professor
• Joseph I. Castro (born 1966) – Chancellor of the California State University.
• Lauro Cavazos (1927–2022) – U.S. Secretary of Education (1988–1990)
• Gery Chico (born 1956) – Chairman of the Illinois State Board of Education, politician and lawyer
• Francisco G. Cigarroa (born 1957) – chancellor of the University of Texas System and president of the UT Health Science Center in San Antonio, Texas.
• Miguel Angel Corzo (born 1942) – CEO and president of LA Plaza de Cultura y Artes
• Maria Cotera (born 1964) – activist, author, researcher, and professor.
• José Cuéllar – professor of Chicano studies
• Robert R. Davila (born 1932) – president of Gallaudet University
• Jorge Calles-Escandón (born 1951) – physician and researcher
• Roberta Fernández – novelist, scholar, critic, and arts advocate professor
• Rosa-Linda Fregoso – professor of Latin American studies
• Miguel García-Garibay – professor of chemistry and the dean of physical sciences at University of California, Los Angeles.
• Alicia Gaspar de Alba (born 1958) – historian, scholar, author
• Ignacio M. Garcia (born 1950) – professor of Western American history
• Juliet V. García – university president
• Laura E. Gómez (born 1964) – president of the Law and Society Association and a professor of law and American studies at the University of New Mexico
• Guillermo Gómez-Peña (born 1955) – performance artist, author, activist and educator
• Juan Gómez-Quiñones (1940–2020) – professor, historian, poet and activist
• Martin Guevara Urbina (born 1972) – writer, researcher, the professor whose work focuses on Latino issues
• José Ángel Gutiérrez (born 1944) – professor and attorney
• Ralph C. Guzmán (1924–1985) – political scientist, professor, author, Deputy Assistant U.S. Secretary of State, provost Merrill College UC Santa Cruz
• Esteban Rossi-Hansberg (born 1973) – professor of economics at Princeton University
• Arturo Islas (1938–1991) – professor of English and novelist
• Kevin Johnson (academic) – Dean of the UC Davis School of Law
• Alejandro L. Madrid (born 1968) – professor of musicology and ethnomusicology at Cornell University
• Juan L. Maldonado (1948–2018) – higher education administrator
• Elizabeth Martinez (librarian) (born 1943) – professor and Executive Director of the American Library Association
• Ramiro Martinez Jr. (born 1962) – professor of criminology
• Miguel Méndez (legal scholar) (c. 1943 – 2017) – law professor and political figure
• Rachel Moran (born 1956) – Dean of UCLA School of Law
• Jonathon J. Andrew Muñoz – philosopher and educator
• William Nericcio (born 1961) – Chicano literary theorist, American Literature scholar, and professor
• J. Michael Ortiz – president emeritus of Cal Poly Pomona
• Juan J. de Pablo (born 1962) – professor in the Institute for Molecular Engineering at the University of Chicago
• Pamela Anne Quiroz (born 1960) – professor of sociology
• Alberto Ríos (born 1952) – Regents' Professor at Arizona State University, educator and author.
• Vicki L. Ruiz (born 1955) – historian, president of the American Historical Association
• Ramón Saldívar (born 1949) – author, professor, and researcher of cultural studies, National Humanities Medal recipient
• Rita Sanchez (born 1937) – academic in the field of Chicano studies
• Hortensia Soto – mathematics professor at Colorado State University
• Richard A. Tapia (1939–2026) – mathematician
• Josefina Villamil Tinajero – president of the National Association for Bilingual Education
• John D. Trasviña (born 1954) – dean of the University of San Francisco School of Law, former Assistant Secretary of the Office of Fair Housing and Equal Opportunity
• Arnulfo Trejo (1922–2002) – writer, college professor, and literary activist
• María Urquides (1908–1994) – K-12 educator, "Mother of Bilingual Education"
• Francisco H. Vázquez (born 1949) – scholar and public intellectual
• María Guillermina Valdes Villalva (1939–1991) – scholar and social activist
• Maria Cristina Villalobos – professor of mathematics
• Erv Wilson (1928–2016) – music theorist
• Leslie Wong (born 1949) – President of San Francisco State University

• Sylvia Acevedo (born 1956/1957) – engineer and businesswoman, worked at NASA's Jet Propulsion Laboratory
• Albert Baez (1912–2007) – physicist and professor, developed the X-ray microscope
• John C. Baez (born 1961) – mathematical physicist
• Elsa Salazar Cade (born 1952) – science educator and entomologist
• Víctor Celorio (born 1957) – inventor of Instabook or book on demand ^[157]
• France A. Córdova (born 1947) – former NASA chief scientist
• Jesús A. De Loera (born 1966) – mathematician at UC Davis
• Teofilo F. Gonzalez (born 1948) – computer scientist and professor
• Sidney M. Gutierrez (born 1951) – former astronaut^[158]
• Guadalupe Hayes-Mota – biotechnologist and business director
• José Hernández (born 1962) – former astronaut^[159]
• Miguel de Icaza (born 1972) – software programmer
• Lydia Villa-Komaroff (born 1947) – molecular and cellular biologist
• Ynes Mexia (1870–1938) – prominent botanist
• Ricardo Miledi (1927–2017) – neuroscientist and professor at University of California, Irvine
• Héctor García-Molina (1953–2019) – computer scientist and professor in the departments of Computer Science and Electrical Engineering at Stanford University
• Mario J. Molina (1943–2020) – co-discoverer of decomposition of ozone with CFC aerosols, Nobel laureate in Chemistry^[160]
• Ellen Ochoa (born 1958) – astronaut, director for flight crew operations for NASA^[161]
• John D. Olivas (born 1965) – NASA astronaut^[162]
• Jorge López (physicist) (born 1955) – physicist and professor
• Alfredo Quiñones-Hinojosa (born 1968) – associate professor of neurosurgery and oncology; director of the Brain Tumor Stem Cell Laboratory at Johns Hopkins University and brain surgeon at Johns Hopkins Hospital
• Paulo Lozano – aerospace engineer at MIT and pioneer in the field of micro-propulsion
• Eloy Rodriguez (born 1947) – biochemist, professor at Cornell University
• Sarah Stewart (1905–1976) – pioneered the field of viral oncology research
• Tedy Taylor (1925–2004) – theoretical physicist and nuclear weapon designer
• Ignacio Tinoco Jr. (1930–2016) – chemist and professor
• Jorge Gardea-Torresdey – chemist and academic
• Nora Volkow (born 1956) – scientist, physician, psychiatrist, great-granddaughter of Leon Trotsky and director of the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH)

• Lucy G. Acosta (1926–2008) – civil rights activist
• Gaylon Alcaraz (born 1970) – community organizer, human rights activist
• Lupe Anguiano (born 1929) – civil rights activist
• Lorena Borjas (1960–2020) – Mexican-born American transgender and immigrant rights activist, known as the mother of the transgender Latinx community in Queens, New York
• Norma V. Cantu (born 1954) – civil rights lawyer and college professor
• Carlos Cadena (1917–2001) – attorney in the landmark Hernandez v. Texas supreme court case
• Adelfa Botello Callejo (1923–2014) – civil rights lawyer
• José Tomás Canales (1877–1976) – civil rights activist and politician active during the early 1900s, played key role in the foundation of the League of United Latin American Citizens.
• Aurora Castillo (1914–1998) – environmental activist
• Sal Castro (1933–2013) – civil rights activist and educator^[163]
• Ernesto Chacon (born 1938) – Latino and low income civil rights activist
• César Chávez (1927–1993) – labor leader, activist, and accused child molester and rapist^[164]
• Linda Chavez-Thompson (born 1944) – former executive vice-president of the AFL–CIO
• Miguel Contreras (1952–2005) – labor leader
• Jeanne Córdova (1948–2016) – lesbian and gay rights activist, writer
• Bert Corona (1918–2001) – labor and community organizer
• Alvina Costilla (born 1926 or 1927) – activist and social worker
• Ricardo Cruz (1943–1993) – attorney, civil rights activist
• Jessie Lopez De La Cruz (1919–2013) – labor organizer
• Maria Echaveste (born 1954) – former White House Deputy Chief of Staff and Senior Fellow at the Center for American Progress
• Josefina Fierro de Bright (1914–1998) – civil rights activist during The Great Depression
• Ernesto Galarza (1905–1984) – labor activist, professor, and writer
• Gustavo C. Garcia (1915–1964) – attorney in the landmark Hernandez v. Texas supreme court case
• Hector P. Garcia (1914–1996) – physician, veteran, and civil rights advocate
• Eva Carrillo de García (1883–1979) – missionary, nurse, and civil-rights activist
• Oscar Gomez (activist) (died 1994) student activist
• Erika Guevara Rosas – human rights lawyer, Americas director at Amnesty International
• Anna Nieto-Gómez (born 1946) – activist and journalist
• Rodolfo Gonzales (1928–2005) – leader of the Chicano civil rights movement, boxer, poet
• José Ángel Gutiérrez (born 1944) – political activist, founder of the Raza Unida party, writer, and professor
• John J. Herrera (1910–1986) – civil rights leader^[165]
• Dolores Huerta (born 1930) – civil rights leader
• Jovita Idar (1885–1946) – journalist, political activist and civil rights worker
• Ralph Lazo (1924–1992) – advocated on behalf of Japanese American internment victims.
• Nativo Lopez (1951–2019) – civil rights activist
• Raul Loya – civil rights activist
• Mimi Lozano (born 1933) – co-founded the Society of Hispanic Historical and Ancestral Research
• Angel G. Luévano (born 1949) – labor leader and activist
• Rueben Martinez (born 1940) – activist and businessman
• Vilma Socorro Martínez (born 1943) – civil rights activist, lawyer and diplomat
• Eliseo Medina (born 1946) – labor activist
• Enrique Morones – immigrant human rights activist
• Janet Murguía (born 1960) – civil rights activist
• Ernesto Nieto (born 1940) – founder of the National Hispanic Institute
• Alex Pacheco (born 1958) – activist
• Julian Samora (1920–1996) – community activist, teacher, and scholar
• Leila Steinberg (born 1961) – educator dedicated to helping at-risk youth find their voice using an emotional literacy curriculum, best known as mentor of rapper Tupac Shakur.
• Olga Talamante (born 1950) – political activist
• Emma Tenayuca (1916–1999) – labor organizer
• Reies López Tijerina (1926–2015) – activist, founder of the Alianza Federal de Mercedes
• John Trudell (1946–2015) – musician, author, poet, and political activist^[102]
• Cristina Tzintzún (born 1982) – organizer, author, and co-founder of the Workers Defense Project
• Baldemar Velasquez (born 1947) – president of the Farm Labor Organizing Committee
• Gustavo Velasquez (born 1972) – Secretary of the Office of Fair Housing and Equal Opportunity
• Delia Villegas Vorhauer (1940–1992) – activist, social worker, and writer
• Vicente T. Ximenes (1919–2014) – civil rights activist, commissioner of EEOC, and chairman of first Presidential Cabinet on Mexican American Affairs
• Raul Yzaguirre (born 1939) – civil rights activist^[166]

• Eusebio L. Elizondo Almaguer (born 1954) – Bishop of the Roman Catholic Archdiocese of Seattle
• Oscar Cantú (born 1966) – Auxiliary Bishop in San Antonio, Texas.^[167]
• Minerva G. Carcaño (born 1954) – Bishop in the United Methodist Church
• Arturo Cepeda (born 1969) – Auxiliary Bishop of the Archdiocese of Detroit
• Gilbert Espinosa Chávez (1932–2020) – Roman Catholic bishop
• Virgilio Elizondo (1935–2016) – Roman Catholic priest, and theologian
• Cirilo Flores (1948–2014) – 5th Bishop of San Diego
• Daniel E. Flores (born 1961) – Bishop of Brownsville
• Patrick Flores (1929–2017) – Roman Catholic bishop
• Elias Gabriel Galvan (born 1938) – retired Bishop of the United Methodist Church
• Naason Joaquin Garcia (born 1969) – current international leader of the La Luz Del Mundo church, sentenced to nearly 17 years in prison for committing acts of sexual abuse against girls from his community^[168] and former pastor of several La Luz Del Mundo churches in California and Arizona between 1994 and 2014^[169][170]
• Richard John Garcia (1947–2018) – bishop of Monterey, California^[171]
• Gustavo García-Siller (born 1950) – Archbishop of the Archdiocese of San Antonio
• José Horacio Gómez (born 1951) – Archbishop of Los Angeles ^[167]
• René Henry Gracida (1923–2026) – bishop
• Joel Nestali Martinez (born 1940) – Bishop in the United Methodist Church
• Peter Morales – president of the Unitarian Universalist Association
• Eduardo Nevares (born 1954) – Auxiliary Bishop of the Diocese of Phoenix
• Jorge Rodríguez-Novelo (born 1955) – Auxiliary Bishop for the Archdiocese of Denver
• Armando Xavier Ochoa (born 1943) – Bishop of El Paso, TX
• Ricardo Ramírez (born 1936) – Bishop of Las Cruzes, New Mexico.^[172]
• Plácido Rodriguez (born 1940) – Bishop of Lubbock, Texas
• Alberto Rojas (born 1965) – Auxiliary Bishop and Episcopal Vicar for the Archdiocese of Chicago.
• Jaime Soto (born 1955) – Roman Catholic coadjutor bishopof Sacramento
• James Anthony Tamayo (born 1949) – Bishop of Laredo, Texas
• Ricardo Watty Urquidi (1938–2011) – Bishop of the Diocese of Tepic in Nayarit, Mexico
• Joe S. Vásquez (born 1957) – Bishop of the Roman Catholic diocese of Austin, Texas.^[173]
• Gabino Zavala (born 1951) – Auxiliary Bishop of the Archdiocese of Los Angeles

• Manuel Abud – media, television, and cable executive
• Linda G. Alvarado (born 1951) – president and chief executive officer of a large commercial and industrial general contracting firm, co-owner of the Colorado Rockies baseball team.
• María Elena Avila (born 1953) – entrepreneur, philanthropist, and civic leader in California
• Michael Ball – fashion mogul
• Hector Barreto Jr. (born 1961) – 21st Administrator of the US Small Business Administration
• Emilio Diez Barroso – chairman and CEO of NALA Investments, a private investment holding company
• Xochi Birch – computer programmer and entrepreneur
• Adolfo Camarillo (1864–1958) – businessman, wealthy landowner, and philanthropist
• Juan Camarillo Jr. (1867–1936) – businessman, wealthy landowner, and philanthropist
• Jovita Carranza (born 1949) – President & CEO of the JCR Group, a consulting firm; former Deputy Administrator for the United States Small Business Administration
• Rudy Chapa (born 1957) – track runner and businessman
• Anna Maria Chávez (born 1968) – CEO of the Girl Scouts of the USA
• Chicano Roy (Roy Suarez Garcia) (1945–2003) – motorbike builder and inventor
• Maria Contreras-Sweet (born 1955) – 24th Administrator of the Small Business Administration, former executive chairwoman and founder of ProAmérica Bank, and California Secretary of Business, Transportation and Housing Agency
• Mike Curb (born 1944) – record company executive, NASCAR car owner, and former Lieutenant Governor of California.^[174]
• William Davila (1931–2014) – first Mexican-American president of a large supermarket chain
• Gérard Louis-Dreyfus (1932–2016) – chairman of Louis Dreyfus Energy Services
• Juan Enríquez (born 1959) – Managing Director of Excel Venture Management, academic, and speaker
• Tavo Hellmund (born 1966) – former racing driver and promoter
• Enrique Hernandez Jr. (born 1955) – business executive, president, and chief executive officer of Inter-Con Security Systems, Inc., and a director of Wells Fargo and McDonald's
• Traci Des Jardins (born 1967) – restaurateur and award-winning chef
• Ninfa Laurenzo (1924–2001) – restaurateur
• Bismarck Lepe – information technology CEO and product manager
• Ignacio E. Lozano Sr. (1886–1953) – founder of La Opinión, the largest Spanish language newspaper in the US
• Ignacio E. Lozano Jr. (born 1927) – newspaper publisher, ambassador, and corporate director
• José I. Lozano (born 1954) – executive vice-president of Impremedia LLC
• Daniel Lubetzky (born 1968) – entrepreneur, author, and activist, best known as the Founder and CEO of KIND LLC.
• David Martinez (born 1957) – managing partner
• Mariano Martinez (entrepreneur) (born 1944) – inventor, entrepreneur, and restaurateur
• Emilio Azcárraga Milmo (1930–1997) – CEO, media mogul
• Richard Montañez – best known for claiming to have invented Flamin' Hot Cheetos
• Kate and Laura Mulleavy (born 1979, born 1980) – fashion designers
• Oscar Munoz (executive) (born 1960) – CEO of United Airlines
• Hugo Morales (radio) – radio executive
• Arturo Moreno (born 1946) – businessman and owner of the Los Angeles Angels
• Rick Owens – fashion designer
• George Paz – CEO of Express Scripts, the largest pharmacy benefit management organization in the US.^[175]
• Dan Peña (born 1945) – financial analyst on Wall Street
• Lisa Garcia Quiroz (1961–2018) – media executive, launched People en Español
• Emilio Romano – managing director of Bank of America Merrill Lynch Mexico
• John Romero (born 1967) – video game developer, co-founder of id Software
• Rosa Rios (born 1965) – 43rd and current treasurer of the United States, businesswoman, executive, and entrepreneur.
• Louis Ruiz (born 1953) – creator of Ruiz Foods, Inc. (Largest Latino owned company in California) ^[176]
• Leslie Sanchez (born 1971) – founder and CEO of Impacto Group LLC, a Washington, D.C.-based market research and consulting firm
• Tony Sanchez (born 1943) – businessman, philanthropist, and Democratic politician
• Felix Tijerina (1905–1965) – restaurateur, activist, and philanthropist
• Solomon Trujillo (born 1951) – CEO and businessman
• Louis Verdad – fashion designer
• Sam Zamarripa (born 1952) – entrepreneur, author, and public official
• Sergio Zyman (born 1945) – marketing executive

• Gregorio Cortez (1875–1916) – Mexican-American outlaw and folk hero
• Joaquin Murrieta (1829–1853) – Mexican bandit or Robin Hood during the California Gold Rush of the 1850s.

• Gustavo Brambila (born 1953) – winemaker in the Napa Valley
• Pati Jinich (born 1972) – Emmy nominated chef, TV personality, cookbook author
• Aarón Sanchez (born 1976) – chef and television personality
• Marcela Valladolid (born 1978) – chef and television host
• Traci Des Jardins – American chef and restaurateur

• Blaire White (born 1993) – YouTuber, political commentator, Internet personality
• Jimmy Santiago Baca (born 1952) – American poet and writer of Apache and Chicano descent
• Johnny Canales (born 1947) – talk show host
• Gregorio Cortez (1875–1916) – Mexican-born and a folk hero to the border communities of the United States and Mexico
• Nick Fuentes (born 1998) – far-right political commentator and live streamer
• Mark Hugo Lopez (born 1967) – Director of Hispanic Research at the Pew Research Center
• Oscar Ozzy Lusth (born 1981) – 1st runner-up on Survivor; Cook Islands
• Jair Marrufo (born 1977) – professional soccer referee
• Edmund McMillen (born 1980) – video game designer and artist
• Raul Melgoza (1975–2020) – fashion designer
• Cesar Millan (born 1969) – TV personality, dog trainer, and author
• Carmen Osbahr (born 1962) – puppeteers Rosita in the children's series Sesame Street
• Albert Pissis (1852–1914) – architect who introduced the Beaux-Arts architectural style to San Francisco
• Richard Ramirez (1960–2013) – serial killer
• Dionicio Rodriguez (1891–1955) – architect
• John Romero (born 1967) – American director, designer, programmer, and developer in the video game industry; co-founder of id Software
• Baldomero Toledo (born 1970) – professional soccer referee
• Edgar Valdez Villarreal (born 1973) – drug lord
• Luis Velador (born 1964) – two-time World Series of Poker bracelet winner
• Eric Volz (born 1979) – entrepreneur, author, and managing director of an international crisis resource agency
• Eduardo Xol (born 1966) – mostly known for his work as a designer on Extreme Makeover: Home Edition

• Notable Hispanics
• Chicano
• List of Mexicans
• List of Mexican British people